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Chargers head into Week 3 searching for answers after opening the 2026 NFL season with two consecutive losses. Their challenge does not get easier Sunday, when Los Angeles visits the unbeaten Buffalo Bills at Highmark Stadium in Orchard Park, New York.
The Chargers are 0-2, while Buffalo has raced to a 2-0 start behind an explosive offense. The Week 3 matchup is scheduled for 1 p.m. ET on Sunday, Sept. 27, with FOX carrying the national broadcast. NFL.com’s group of analysts unanimously selected the Bills to win, making this one of the clearest consensus picks of the weekend.
Chargers Face a Critical Test Against Josh Allen
Buffalo quarterback Josh Allen has been one of the league’s most productive players through the opening two games. He has already accounted for nine touchdowns, including five passing scores and four rushing touchdowns. The Bills have also scored at least 36 points in each of their first two contests.
That production puts immediate pressure on the Chargers defense. Although Buffalo has shown some vulnerability on that side of the ball, its ability to sustain scoring drives has made the Bills one of the NFL’s most dangerous early-season teams.
Los Angeles, meanwhile, has struggled to find consistency under Mike McDaniel’s new offensive system. Justin Herbert has looked uncomfortable at times, while several pass catchers have been limited by injuries and costly drops. Running back Omarion Hampton has also lost a fumble in each of the Chargers’ first two games.
Explosive Bills Offense Towers Over Los Angeles
The betting market reflects the difficult assignment facing the Chargers. Buffalo opened as a heavy favorite at -7.5, with a moneyline of -370. The total was listed at 50.5 points, suggesting expectations for another high-scoring Bills performance.
NFL.com’s five analysts all predicted a Buffalo victory. Their projected scores ranged from a 26-14 Bills win to a more decisive 38-20 result. Other predictions included 33-24, 28-21 and 34-20, with every selection pointing to Buffalo improving to 3-0.
- Location: Highmark Stadium, Orchard Park, New York
- Kickoff: 1 p.m. ET, Sunday, Sept. 27
- Broadcast: FOX
- Spread: Buffalo -7.5
- Over/under: 50.5 points
Can the Chargers Rebound on the Road?
Los Angeles still has a path to an upset, but it likely begins with protecting the football and creating longer, more efficient drives. Herbert will need improved timing from his receiving corps, while the running game must avoid the mistakes that have stalled the offense early in the season.
The Chargers also need their defense to keep Allen from controlling the game immediately. Buffalo’s quarterback can hurt opponents from the pocket and with his legs, making red-zone discipline and third-down defense especially important.
The matchup is also a test of resilience. Only two games have been played, but the Chargers are already facing considerable pressure to avoid falling to 0-3. Historically, teams that begin a season with three losses rarely reach the playoffs, although last year’s Texans were cited as an exception in the NFL.com analysis.
For Buffalo, the goal is more straightforward: continue the momentum, protect home field and establish itself as an early AFC contender. The Bills’ defense may still have questions to answer, but Allen and the offense have provided more than enough firepower so far.
What the Week 3 Prediction Means
The consensus does not guarantee the outcome, but it highlights the gap between the teams’ early-season form. The Bills have looked confident and efficient, while the Chargers are still working through a new scheme, offensive mistakes and injury concerns.
A strong performance from Herbert could change the narrative quickly. However, unless Los Angeles limits turnovers and keeps pace on the scoreboard, Buffalo appears positioned to deliver another powerful home victory.
Frequently Asked Questions
When do the Chargers play the Bills?
The Chargers visit the Buffalo Bills at 1 p.m. ET on Sunday, Sept. 27, 2026.
What is the Chargers’ record entering Week 3?
Los Angeles enters the matchup with an 0-2 record after losing its first two games of the season.
What is Buffalo’s record?
The Bills are 2-0 and have scored at least 36 points in both of their opening games.
Who is favored to win the game?
Buffalo is favored by 7.5 points, and all five NFL.com analysts selected the Bills to win.
What is the key matchup?
The most important battle may be between Josh Allen and the Chargers defense, particularly whether Los Angeles can limit his passing production, rushing ability and red-zone impact.
